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Following the integrated concept of the GRK1910 all research projects are highly collaborative and interdisciplinary. Doctoral projects are supervised by at least 3 group leaders. The name of the primary supervisor of each project is given below. The majority of projects are aimed to be handles by a graduate student within three-year doctoral studies. Additionally, some projects are designed to give talented postdoctoral researches the opportunity to further qualify and to take advantage of the interdisciplinary environment of the GRK1910 for up to 2 years.
Following an integrated concept, 13 collaborative doctoral Projects are addressed within the research Training Group. Additionally, postdoctoral projects are intended to promote the careers of highly talented and motivated junior scientists and to improve networking between the project groups by exploring new approaches and techniques of particular importance in the field.
The projects, which are assigned to the research areas A, B and C, aim to better understand selectivity principles of GPCR-ligand interactions and to exploit this knowledge for a rational design of highly selective GPCR ligands. The project proposals P are intended to promote the careers of highly talented and motivated junior scientists and to improve networking between the project groups by exploring new approaches and techniques of particular importance in the field.
A) Selective GPCR-ligand interactions
Projects to understand and control selectivity; Structure or ligand based design, ligand synthesis, binding studies and functional assays, mutagenesis discovery of ligands with novel selectivity profiles.
B) Selective GPCR tracers and tools
Synthetically driven projects establish crucial methodology and apply for tools (PET ligands, switchable ligands).
C) Selective GPCR-mediated signal transduction
Projects to develop and apply individual assays to characterize selective ligands integratively (proteomics, label-free assays, ion channel modulation).
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